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Case Report
CD56, CD68 positive double hit, diffuse large B-cell/high-grade B-cell lymphoma with rearrangement of MYC and BCL2 genes
1 Hemathopathology, Clinical Pathology Laboratory, INCYTE Diagnostics, Spokane, WA, USA
2 Surgical Pathology/Dermatopathology, Anatomic Pathology Laboratory, INCYTE Diagnostics, Tukwila, WA, USA
3 Laboratory Assistant, Anatomic Pathology Laboratory, INCYTE Diagnostics, Tukwila, WA, USA
Address correspondence to:
Solomon Tessega
Sea Tac, WA,
USA
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Article ID: 100013P03JA2025
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Andrews J, Long T, Tessega S. CD56, CD68 positive double hit, diffuse large B-cell/high-grade B-cell lymphoma with rearrangement of MYC and BCL2 genes. Edorium J Pathol 2025;9(1):1–5.ABSTRACT
Introduction: This is a report of diffuse large B-cell/high-grade B-cell lymphoma (DLBCL/HGBL)-MYC/BCL2 with CD56 and CD68 immunoreactivity, pseudopapillary architecture, and pleomorphic nuclei with multinucleation arising in the nasal cavity. This combination of features makes this a highly unusual case that contributes to our understanding of rare histopathologic and immunophenotypic features in DLBCL.
Case Report: A 64-year-old male has been diagnosed with double-hit, diffuse large B-cell lymphoma (DLBCL). Pathological examination revealed large, variably multinucleated anaplastic cells with multilobulated nuclei surrounding a vascular core and exhibiting a pseudopapillary growth pattern, all set against reactive lymphocytes and histiocytes. Further studies showed the tumor’s positivity for CD56 and CD68, along with other positive immunohistochemical (IHC) markers.
Conclusion: Additional investigations could contribute to understanding the clinical, prognostic, and diagnostic significance of unusual pathologic features in DLBCL and its subtypes.
Keywords: CD56, CD68, Diffuse large B-cell lymphoma, Immunohistochemistry, Pseudopapillary growth pattern
SUPPORTING INFORMATION
Author Contributions:
Jared Andrews - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Thomas Long - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Solomon Tessega - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Jared Andrews et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
