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Case Report
Primary osteosarcoma of the breast: A case report
1 Resident, Department of Anatomopathology, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, Morocco
2 Professor, Department of Anatomopathology, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, Morocco
3 Resident, Department of Gynecology and Obstretrics, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, Morocco
4 Professor, Department of Gynecology and Obstretrics, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, Morocco
5 Professor and Chief of Anatomopathology Department, Department of Anatomopathology, Ibn Rochd University Hospital Center, Hassan II University of Casablanca, Faculty of Medicine and Pharmacy, Casablanca, Morocco
Address correspondence to:
Evrard Niyonkuru
Casablanca,
Morocco
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Article ID: 100011P03EN2021
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Niyonkuru E, Regragui M, Sami Z, Nihad DSF, Elkarroumi M, Karkouri M. Primary osteosarcoma of the breast: A case report. Edorium J Pathol 2021;7:100011P03EN2021.ABSTRACT
Introduction: Primary osteosarcoma of the breast is an extremely rare malignant tumor, and only few cases have been reported in the literature. It is a rare histological type of all breast tumors. Primary osteosarcoma of the breast is considered to be an aggressive tumor with a poor prognosis.
Case Report: We report a case of primary osteosarcoma of the breast in a 71-year-old woman. The patient presented a lump in the left breast, discovered on self-examination. Ultrasound and mammographic data revealed a large solid and cystic mass in the left breast, graded as highly suggestive of malignancy (Breast Imaging and Reporting Data System [BI-RADS] category 5). After a tru-cut biopsy showing a malignant mesenchymal tumor proliferation, the patient has undergone a mastectomy. The histological examination of the mastectomy specimen revealed the presence of sarcomatous proliferation with abundant osteoid substance and chondroid area but no epithelial component. The diagnosis of primary osteosarcoma of the breast was determined after ruling out the primary differential diagnosis, metaplastic carcinoma, by an immunohistochemical study. Immunohistochemically, tumor cells were non-reactive with anti-cytokeratin antibodies.
Conclusion: It is essential to recognize this rare and aggressive pathologic tumor variant in order to manage patients suffering from this pathology appropriately.
Keywords: Breast cancer, Histology, Mastectomy, Primary osteosarcoma
SUPPORTING INFORMATION
Author Contributions:
Evrard Niyonkuru - Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Meriem Regragui - Substantial contributions to conception and design, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Zineb Sami - Acquisition of data, Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Da Silva Fidélia Nihad - Acquisition of data, Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Mohamed Elkarroumi - Substantial contributions to conception and design, Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Mehdi Karkouri - Substantial contributions to conception and design, Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Evrard Niyonkuru et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
